INHERITANCE OF ANTIBODY SPECIFICITY
نویسندگان
چکیده
منابع مشابه
Inheritance of Antibody Specificity
Our data suggest that fine specificity of antihapten antibodies is a useful Mendelian marker of variable (V) genes. We found that some mouse strains (e.g., C57/BL6) consistently produced heteroclitic anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies (relative affinity for related (4-hydroxy-5-iodo-3-nitrophenyl)acetyl and (4-hydroxy-3.5-dinitrophenyl)acetyl was always >2) while other strains...
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Antibodies to hapten 2-phenyloxazolone (phOx) of all BALB/c and DBA/2 mice have the same idiotype and the same major (public) isoelectric focusing pattern whose main spectrotype is called Ox-1. Neither of these characteristics could be readily demonstrated in anti-phOx antibodies of C57BL, C3H or LP mice; these antibodies were heterogeneous, and lacked public spectrotypes. Also, a fine specific...
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Mice of 17 inbred strains produced anti-(4-hydroxy-5-bromo-3-nitrophenyl)-acetyl (NBrP) of three different fine specificity types. Anti-NBrP antibodies of all allotype b mice (five strains tested) had a high relative affinity for (4-hydroxy-3.5-dinitrophenyl) acetyl (NNP) but low for (4-hydroxy-5-cloro-3-nitrophenyl) acetyl (NCP). Another category was characterized by high relative affinity for...
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When specificity considerations are incorporated in default reasoning systems, it is hard lo ensure that exceptional subclasses inherit all legitimate features of their parent classes To reconcile these two requirements specificitv and inheritance, this paper proposes the addi tion of a new rule called coherence rule, to the desiderata for default inference The coherence rule captures the intu...
متن کامل924 Antibody Fine Specificity
Standard immune responses are the sum of many clonal responses, cross-reactive and specific. Any study of clonal expression as well as analysis of its products requires the separation of clones. There are several approaches to this goal (1-3). The one we used was to generate immune responses of restricted heterogeneity where a limited number ofclonotypes determine the response (4, 5). The prere...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1974
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.140.6.1498